Envigo is continuously monitoring, preparing and updating its guidance to customers as we approach the key dates of the Article 50 separation of the United Kingdom from the European Union (aka “Brexit”). Envigo established a Brexit task force consisting of senior leadership from key areas of our business to ensure ongoing business continuity for both Envigo and its customers.
This task force continues to meet regularly in order to prepare and implement business process plans and resourcing to anticipate and minimize the impact of Brexit on our business. The following FAQs have been prepared as current guidance and is continually updated as the position between the British Government and the EU develops.
Brexit is a priority for Envigo and if you have any concern, please contact us at brexit@envigo.com.
Will there be tariffs applied to animal costs under WTO?
Laboratory animals currently have no tax added for movement in to the EU and across the EU, this position will remain the same under WTO
Prices for 2021 are being reviewed as normal and will be confirmed in due course.
Will there be changes in documentation needed for movements of animals in or out of the UK?
Import to UK Changes: Envigo’s current understanding is that there will be limited change in terms of documentation required.
DEFRA have now confirmed that no additional vet checks on arrival will be required
Also customers can use the AHPA License for the import into the UK of live rodents or lagomorphs for research. Our Customer Services team are talking to the relevant customers and can advise any new customers as required
Our Customer Services team is working directly with customers to make the necessary changes to Incoterms
Export from UK Changes: Envigo understands that the export documentation will need to be agreed with the EU and may require an additional licence per shipment. This may take an additional time to secure plus an additional vet check may be required prior to shipment. We are working with EU groups to clarify this position and will update customers once a firm position is confirmed.
Documentation: Exact documentation requirements are to be clarified, please contact your customer services representative if you have immediate concerns.
Will there be any other impact on the movement of animals in and out of the UK?
The main impact we currently predict is additional delays in shipments due to:
Export license requests may add time to the process from PO to shipment for small animals being shipped from the UK to the EU. Vet checks might be required at Border Inspection Posts at the airport of arrival.
Additional CITES might be required and thus may add additional time for shipments of animals requiring to travel under CITES from the EU to the UK.
Will there be tariffs on any other goods imported in and out of the UK under WTO?
Under WTO terms the Envigo team have assessed that there will be additional tariffs on certain goods including our Teklad diet shipments into the UK. Additional costs are being assessed and any cost impact to clients will be conveyed to customers via our commercial sales team as soon as possible.
Has Envigo ensured that its supply chain for its Operations are ready for the change on 1st Jan?
Envigo’s Procurement team continues to work with it’s key suppliers in the UK to ensure that supply chains are secure for the post Brexit period. The team are encouraging suppliers to ensure that they have sufficient stock to cover any transition period at the beginning of January.
What will the impact be on the movement of biological products (UK to customer EU and EU to UK)?
We are working with the governmental authorities in the relevant countries together with our international couriers to determine labelling / commercial invoice / payment of VAT / export license & vet check requirements. We will update all parties once further clarity is obtained. We are sure that this will be determined to ensure continuity of these services as we transition to the post Brexit position.
Does Envigo think movement of animals in and out of the UK will have the changes in place ready for 1st Jan?
Envigo recommends that its clients do not request animals deliveries in or out of the UK during the first two weeks of January in order to ensure that all changes at borders and documentation are in place. If there is a requirement for a shipment early in January we would request that you contact your customer services representative as early as possible in December order that the necessary plans can be put in place.
Are there any specific concerns in relation to shipments to Ireland?
The changes in movement of goods from UK to both Northern and Southern Ireland is still unknown – further clarification will be provided when we have more information.
Talent
What proportion of Envigo’s UK employees are EU nationals?
Less than 6% of Envigo’s UK employees are EU nationals. We have worked with all of these employees to ensure they have the relevant rights to live / work in the UK or EU as appropriate
What is Envigo’s expectation of the impact of immigration challenges to staffing your UK-based operation?
This is not expected to have significant impact as Envigo has separate distribution centres in both the UK and EU to enable us to continue to operate under the most favourable trading environment for our customers regardless of trading arrangements between the UK and the EU, or between the UK, EU and the rest of the world. We are committed to recruiting and retaining the best people and to pursue our mission to be the best company to work with and the best company to work for.
Financial
What will be the impact on Envigo’s finances?
Envigo is financially stable and resilient: Though there might be minor changes arising from the Brexit transition, we believe that there will not be any significant adverse impact to the business and we will continue to invest in world-class operations and innovation post Brexit.
Impact of exchange rate movements on costs, profitability and competitive position
Exchange rate movements are an inevitable fact of the business environment and occur because of numerous factors including, inflation, government fiscal policy, real gross domestic product GDP and expectations around future economic performance and the impact of speculative currency investment. In this regard, they are not deemed to be solely a Brexit specific issue. Exchange rate risk is mitigated by Envigo due it being an international business, which has regional operational centres in proximity to the customer base incurring costs in the same currency of sale.
Data Protection/GDPR
What is will be the status of the General Data Protection Regulation (2016/679) (GDPR) after the transition period.
The UK is committed to maintaining the high standards of the GDPR and the government plans to incorporate it via the European Union (Withdrawal) Act 2018 into UK law alongside the Data Protection Act 2018, at the end of the transition period.
What safeguards will be in place for 1. UK to EEA Personal Data flows; 2. EEA to UK Personal Data flows; and, 3. UK sharing data outside the EEA after the transition period?
The UK government has stated that transfers of Personal Data to the EEA will not be restricted and that no additional steps are necessary at this time.
The European Commission is presently deliberating on an adequacy decision under Article 45(3) of the GDPR which would enable the transfer of personal data from EEA states to the UK without requiring any further safeguards. Pending such an adequacy decision or in the absence thereof, Envigo is putting in place approved safeguards in the form of standard contractual clauses.
Rules for sharing data with countries outside the EEA will remain similar.The UK government has confirmed that there will be transitional provisions to recognise existing EU adequacy decisions and EU-approved transfers safeguards.
Other
What Brexit scenario is Envigo planning for?
At this stage Envigo is planning for a “no-deal” scenario and have put the necessary actions in place to manage its business on this basis
Has Envigo undertaken an internal assessment of what impact Brexit will have on customer’s business operations?
Yes, Envigo continues to assess the potential impact of Brexit on both our customers and suppliers. In response to Brexit we have:
Our internal task force is continuously assessing the overall business risks
Developing a range of contingency plans to mitigate the effects
Envigo are taking a leading role and working with various industry associations. ABPI, BIA, EARA, and UK government departments (e.g. DEFRA, Home office, Her Majesty’s Revenue and Customs (HMRC)). At this stage there are still uncertainties on specific issues e.g. CITES and as such there are still risks that we continue to try and mitigate against. As a result, we would recommend that cross border shipment in the first two weeks of January be avoided.
Have you developed a plan to mitigate the Brexit risks you have identified?
Yes, and are already initiating action and contingency plans to address potential impacts on our business based upon our current understanding.
Does Envigo review and adjust plans based on Brexit negotiations and wider external events?
Yes, our internal task force is continuously assessing the overall business risks, to ensure the plans are both relevant and appropriate to the current political situation.
Whom may we contact to follow up on the responses to Brexit mitigation plans?
An e-mail address has been established: brexit@envigo.com. This is available for use to allow any specific follow up questions to be raised that you might have in relation to Envigo’s Brexit mitigation plans.
Glossary
ABPI
Association of British Pharmaceutical Industry
BIA
Bioindustry Association
CLP
Classification, Labelling and Packaging
CITES
Convention on International Trade in Endangered Species of Wild Fauna and Flora (also known as the Washington Convention)
DEFRA
Department for Environment, Food and Rural Affairs
DPB
Data Protection Bill
EARA
European Animal Research Association
EU27
European Union (the 27 European Union countries involved in Brexit negotiations)
There are numerous possibilities in adjusting both the level and source of fat in a diet. If your primary interest is inducing atherosclerosis or obesity, additional information can be found on our Teklad atherogenic and diet induced obesity (DIO) diet pages. Depending on your research goals and level of desired fat supplementation, fats can be added to a standard natural ingredient diet or a purified diet.
Purified ingredients are refined to the point of chemical simplicity and allow for extreme fat levels such as no fat diet TD.03314 or very high fat ketogenic diet TD.96355 . Unless adjustments are made to the level of fiber, diets with high fat levels will have a greater caloric density since fat contains 9 kcal/g versus 4 kcal/g for carbohydrate or protein. Animals are good at regulating caloric intake, therefore it is common to adjust other nutrients (vitamins, minerals, protein) relative to energy content to account for differences in feed intake.
Specific fats can be utilized as in this essential fatty acid deficient diet TD.84224 or to provide high levels of omega-3 polyunsaturated fat from flaxseed or fish oil. Normally, 1-2% fat from plant sources like corn or soybean oil will supply sufficient levels of essential fatty acids. Additional fat provides energy and can influence palatability due to effects on taste and texture of the diet.
Mixtures of fats can be used to mimic a Western or Mediterranean diet fatty acid profile. Contact us for a table comparing the fatty acid composition of several stocked fat sources (solid fats, oils).
We also commonly work with customer supplied oils and purified fatty acids such as DHA and EPA. If you prefer to mix fat sources in your lab, ask about a basal mix. Basal mixes are supplied in powder form and often allow you to use one diet mix for creating several different diets.
If fat stability is a concern, contact a nutritionist to discuss options for diet drying, vacuum packaging, and synthetic antioxidant supplementation.
You may want to add some specific ingredients in your own facility. In that case, Envigo provides basal mixes that are, by design, a starting point for additional inclusions. When you choose a basal mix diet, you simply add any ingredient(s) in a specific proportion that your require. The nutrient levels in our basal mix are adjusted to account for the dilution of the added ingredient(s), so that the final complete diet contains the desired nutrient levels.
Envigo respects your privacy and is committed to protecting your personal data. This privacy notice will inform you what personal information we may collect about you when you interact with Envigo and its group of companies (“Envigo,” “we,” “us,” and “our,”), how we look after your personal data and tell you about your privacy rights and how the law protects you.
It is important that you read this Privacy Policy together with any other privacy notice or fair processing notice we may provide on specific occasions when we are collecting or processing personal data about you so that you are fully aware of how and why we are using your data.
This privacy notice supplements the other notices and is not intended to override them. We may change this Privacy Policy from time to time.
This website is not intended for children and we do not knowingly collect data relating to children.
Third-party links
This website may include links to third-party websites, plug-ins and applications. Clicking on those links or enabling those connections may allow third parties to collect or share data about you. We do not control these third-party websites and are not responsible for their privacy statements. When you leave our website, we encourage you to read the privacy notice of every website you visit.
1. The data we collect about you
Personal data, or personal information, means any information about an individual from which that person can be identified. It does not include data where the identity has been removed (anonymous data).
We may collect, use, store and transfer different kinds of personal data about you which we have grouped together follows:
Identity Data includes first name, last name, username or similar identifier, title, date of birth and gender.
Contact Data includes, email address and telephone numbers, job title, IP Address, employer.
Technical Data includes internet protocol (IP) address, your login data, browser type and version, time zone setting and location, browser plug-in types and versions, operating system and platform and other technology on the devices you use to access this website.
Profile Data includes your username, areas of research, areas of interest, preferences, feedback and survey responses, role in purchasing
Usage Data includes information about how you use our website.
Marketing and Communications Data includes your preferences in receiving marketing from us and our third parties and your communication preferences.
We also collect, use and share Aggregated Data such as statistical or demographic data for any purpose. Aggregated Data may be derived from your personal data but is not considered personal data in law as this data does not directly or indirectly reveal your identity. For example, we may aggregate your Usage Data to calculate the percentage of users accessing a specific website feature. However, if we combine or connect Aggregated Data with your personal data so that it can directly or indirectly identify you, we treat the combined data as personal data which will be used in accordance with this Privacy Policy.
If you fail to provide personal data
Where we need to collect personal data by law, or under the terms of a contract we have with you and you fail to provide that data when requested, we may not be able to perform the contract we have or are trying to enter into with you (for example, to provide you with goods or services). In this case, we may have to cancel a product or service you have with us but we will notify you if this is the case at the time.
2. How is your personal data collected?
We use different methods to collect data from and about you including through:
Direct interactions. You may give us your Identity and Contact by filling in forms or by corresponding with us by post, phone, email, website, digital platforms or otherwise. This includes personal data you provide when you:
apply for our products or services;
subscribe to our service or publications;
request access to or be sent marketing content
enter a competition, promotion, survey or register for an event; or
give us some feedback.
Automated technologies or interactions. As you interact with our website, we may automatically collect Technical Data about your equipment, browsing actions and patterns. We collect this personal data by using cookies, server logs and other similar technologies. We may also receive Technical Data about you if you visit other websites employing our cookies. Please see our cookie statement for further details.
Third parties or publicly available sources. We may receive personal data about you from various third parties and public sources as set out below:
Technical Data from the following parties: (a) analytics providers such as Google based outside the EU, (b) advertising networks, (c) search information providers.
Identity and Contact Data from publicly availably sources such as relevant Company Registers.
3. How we use your personal data
We will only use your personal data when the law allows us to. Most commonly, we will use your personal data in the following circumstances:
Where we need to perform the contract we are about to enter into or have entered into with you.
Where it is necessary for our legitimate interests (or those of a third party) and your interests and fundamental rights do not override those interests.
Where we need to comply with a legal or regulatory obligation.
Where it is necessary to protect the vital interests of the individual or another person.
Generally we do not rely on consent as a legal basis for processing your personal data other than in relation to sending direct marketing communications. You have the right to withdraw consent to marketing at any time by visiting our contact preference center or by contacting us directly. A link to our contact preference center is available in all email communications.
Purposes for which we will use your personal data
We have set out below, in a table format, a description of all the ways we plan to use your personal data, and which of the legal bases we rely on to do so. We have also identified what our legitimate interests are where appropriate.
Note that we may process your personal data for more than one lawful ground depending on the specific purpose for which we are using your data. Please contact us if you need details about the specific legal ground we are relying on to process your personal data where more than one ground has been set out in the table below.
Purpose/Activity
Type of data
Lawful basis for processing including basis of legitimate interest
To register you as a new customer
(a) Identity (b) Contact
Performance of a contract
To manage our relationship with you which will include: (a) Notifying you about changes to our terms or Privacy Policy (b) Asking you to leave a review or take a survey.
(a) Identity (b) Contact (c) Profile (d) Marketing and Communications
(a) Performance of a contract with you (b) Necessary to comply with a legal obligation (c) Necessary for our legitimate interests (to keep our records updated and to study how customers use our products/services)
To enable you to complete a survey, sign up for an event, subscribe for information or updates.
(a) Performance of a contract with you (b) Necessary for our legitimate interests (to study how customers use our products/services, to develop them and grow our business)
To administer and protect our business and this website (including troubleshooting, data analysis, testing, system maintenance, support, reporting and hosting of data)
(a) Identity (b) Contact (c) Technical
(a) Necessary for our legitimate interests (for running our business, provision of administration and IT services, network security, to prevent fraud and in the context of a business reorganisation or group restructuring exercise) (b) Necessary to comply with a legal obligation
To deliver relevant website content, general marketing and messaging to you and measure or understand the effectiveness of the advertising we serve to you
Necessary for our legitimate interests (to study how customers use our products/services, to develop them, to grow our business and to inform and measure our marketing strategy)
To use data analytics to improve our website, products/services, marketing, customer relationships and experiences
(a) Technical (b) Usage
Necessary for our legitimate interests (to define types of customers for our products and services, to keep our website updated and relevant, to develop our business and to inform our marketing strategy)
To make suggestions and recommendations to you about goods or services that may be of interest to you
Necessary for our legitimate interests (to develop our products/services and grow our business)
Marketing
We strive to provide you with choices regarding certain personal data uses, particularly around marketing and advertising, via the contact preference center, available in all email communications, or by contacting us at any time.
Promotional offers from us
We may use your Identity, Contact, Technical, Usage and Profile Data to form a view on what we think you may want or need, or what may be of interest to you. This is how we decide which products, services and offers may be relevant for you.
You will receive marketing communications from us if you have requested information from us or purchased goods or services from us or if you provided us with your details when you entered a competition, registered for a promotion or for an event and, in each case, you have not opted out of receiving that marketing.
Third-party marketing
We will get your express opt-in consent before we share your personal data with any company outside the Envigo group of companies for marketing purposes.
Opting out
You can ask us to stop sending you marketing messages at any time via the contact preference center, available in all email communications, or by contacting us at any time.
Where you opt out of receiving these marketing messages, this will not apply to personal data provided to us as a result of a product/service purchase, product/service experience or other transactions.
Cookies
You can set your browser to refuse all, or to alert you when websites set or access cookies. If you disable or refuse cookies, please note that some parts of this website may become inaccessible or not function properly. For more information about the cookies we use, please see our cookie statement.
Change of purpose
We will only use your personal data for the purposes for which we collected it, unless we reasonably consider that we need to use it for another reason and that reason is compatible with the original purpose. If we need to use your personal data for an unrelated purpose, we will notify you and we will explain the legal basis which allows us to do so.
Please note that we may process your personal data without your knowledge or consent, in compliance with the above rules, where this is required or permitted by law.
4. Disclosures of your personal data
We may have to share your personal data with the parties set out below for the purposes set out in the table in paragraph 3 above.
Internal Third Parties as set out in the Glossary below.
External Third Parties as set out in the Glossary below.
Third parties to whom we may choose to sell, transfer, or merge parts of our business or our assets. Alternatively, we may seek to acquire other businesses or merge with them. If a change happens to our business, then the new owners may use your personal data in the same way as set out in this privacy notice.
We require all third parties to respect the security of your personal data and to treat it in accordance with the law. We do not allow our third-party service providers to use your personal data for their own purposes and only permit them to process your personal data for specified purposes and in accordance with our instructions.
5. International transfers
We share your personal data within the Envigo Group. This will involve transferring your data outside the European Economic Area (EEA).
Some of our external third parties are based outside the European Economic Area (EEA) so their processing of your personal data will involve a transfer of data outside the EEA.
Whenever we transfer your personal data out of the EEA, we ensure a similar degree of protection is afforded to it by ensuring at least one of the following safeguards is implemented.
We will only transfer your personal data to countries that have been deemed to provide an adequate level of protection for personal data by the European Commission.
Where we use certain service providers, we may use specific contracts approved by the European Commission which give personal data the same protection it has in Europe.
Where we use providers based in the US, we may transfer data to them if they are part of the Privacy Shield (to the extent that it continues to provide adequate safeguards) which requires them to provide similar protection to personal data shared between the Europe and the US. For further details, see European Commission: EU-US Privacy Shield.
6. Data security
We have put in place appropriate security measures to prevent your personal data from being accidentally lost, used or accessed in an unauthorized way, altered or disclosed. In addition, we limit access to your personal data to those employees, agents, contractors and other third parties who have a business need to know. They will only process your personal data on our instructions and they are subject to a duty of confidentiality.
We have put in place procedures to deal with any suspected personal data breach and will notify you and any applicable regulator of a breach where we are legally required to do so.
7. Data retention
How long will you use my personal data for?
We will only retain your personal data for as long as necessary to fulfil the purposes we collected it for, including for the purposes of satisfying any legal, accounting, or reporting requirements.
To determine the appropriate retention period for personal data, we consider the amount, nature, and sensitivity of the personal data, the potential risk of harm from unauthorised use or disclosure of your personal data, the purposes for which we process your personal data and whether we can achieve those purposes through other means, and the applicable legal requirements.
In some circumstances you can ask us to delete your data: see Request erasure below for further information.
In some circumstances we may anonymise your personal data (so that it can no longer be associated with you) for research or statistical purposes in which case we may use this information indefinitely without further notice to you.
8. Your legal rights
Under certain circumstances, you have rights under data protection laws in relation to your personal data. You may be entitled to:
Request access to your personal data.
Request correction of your personal data.
Request erasure of your personal data.
Object to processing of your personal data.
Request restriction of processing your personal data.
Request transfer of your personal data.
Right to withdraw consent.
You also have the right to complain to your local data protection authority if your privacy rights are violated, or if you have suffered as a result of unlawful processing of your personal information. We would however welcome the opportunity to resolve any issue that you have.
If you wish to exercise any of the rights set out above, please contact us.
No fee usually required
You will not have to pay a fee to access your personal data (or to exercise any of the other rights). However, we may charge a reasonable fee if your request is clearly unfounded, repetitive or excessive. Alternatively, we may refuse to comply with your request in these circumstances.
What we may need from you
We may need to request specific information from you to help us confirm your identity and ensure your right to access your personal data (or to exercise any of your other rights). This is a security measure to ensure that personal data is not disclosed to any person who has no right to receive it. We may also contact you to ask you for further information in relation to your request to speed up our response.
Time limit to respond
We try to respond to all legitimate requests within one month. Occasionally it may take us longer than a month if your request is particularly complex or you have made a number of requests. In this case, we will notify you and keep you updated.
9. Glossary
LAWFUL BASIS
Legitimate Interest means the interest of our business in conducting and managing our business to enable us to give you the best service/product and the best and most secure experience. We make sure we consider and balance any potential impact on you (both positive and negative) and your rights before we process your personal data for our legitimate interests. We do not use your personal data for activities where our interests are overridden by the impact on you (unless we have your consent or are otherwise required or permitted to by law). You can obtain further information about how we assess our legitimate interests against any potential impact on you in respect of specific activities by contacting us.
Performance of Contract means processing your data where it is necessary for the performance of a contract to which you are a party or to take steps at your request before entering into such a contract.
Comply with a legal or regulatory obligation means processing your personal data where it is necessary for compliance with a legal or regulatory obligation that we are subject to.
THIRD PARTIES
Internal Third Parties
Other companies in the Envigo Group acting as joint controllers or processors and who are based in the USA, Europe and ROW and provide products and services and IT and system administration services and undertake leadership reporting.
External Third Parties
Service providers acting as processors who provide IT and system administration services.
Professional advisers acting as processors or joint controllers including lawyers, bankers, auditors and insurers who provide consultancy, banking, legal, insurance and accounting services.
HM Revenue & Customs, regulators and other authorities acting as processors or joint controllers who require reporting of processing activities in certain circumstances.
YOUR LEGAL RIGHTS
You have the right to:
Request access to your personal data (commonly known as a “data subject access request”). This enables you to receive a copy of the personal data we hold about you and to check that we are lawfully processing it.
Request correction of the personal data that we hold about you. This enables you to have any incomplete or inaccurate data we hold about you corrected, though we may need to verify the accuracy of the new data you provide to us.
Request erasure of your personal data. This enables you to ask us to delete or remove personal data where there is no good reason for us continuing to process it. You also have the right to ask us to delete or remove your personal data where you have successfully exercised your right to object to processing (see below), where we may have processed your information unlawfully or where we are required to erase your personal data to comply with local law. Note, however, that we may not always be able to comply with your request of erasure for specific legal reasons which will be notified to you, if applicable, at the time of your request.
Object to processing of your personal data where we are relying on a legitimate interest (or those of a third party) and there is something about your particular situation which makes you want to object to processing on this ground as you feel it impacts on your fundamental rights and freedoms. You also have the right to object where we are processing your personal data for direct marketing purposes. In some cases, we may demonstrate that we have compelling legitimate grounds to process your information which override your rights and freedoms.
Request restriction of processing of your personal data. This enables you to ask us to suspend the processing of your personal data in the following scenarios: (a) if you want us to establish the data’s accuracy; (b) where our use of the data is unlawful but you do not want us to erase it; (c) where you need us to hold the data even if we no longer require it as you need it to establish, exercise or defend legal claims; or (d) you have objected to our use of your data but we need to verify whether we have overriding legitimate grounds to use it.
Request the transfer of your personal data to you or to a third party. We will provide to you, or a third party you have chosen, your personal data in a structured, commonly used, machine-readable format. Note that this right only applies to automated information which you initially provided consent for us to use or where we used the information to perform a contract with you.
Withdraw consent at any time where we are relying on consent to process your personal data. However, this will not affect the lawfulness of any processing carried out before you withdraw your consent. If you withdraw your consent, we may not be able to provide certain products or services to you. We will advise you if this is the case at the time you withdraw your consent.
Envigo’s customers conduct research and develop products that have the potential to improve lives. But achieving this potential is becoming increasingly difficult.
We believe that for our customers to achieve their goals, they need to trust and be absolutely confident in the company they choose to help them with their research, products and services.
We understand the only way we can create this trust and confidence is by consistently delivering scientific excellence and outstanding customer service.
At Envigo, we are proud of our customer-centric culture which makes us responsive to every customer, no matter their size, continually optimizing their product delivery and research programs to help ensure consistently clear results.
Our ability to combine scientific excellence with empathetic working relationships is what differentiates us. We always seek to understand our customers’ goals and challenges, appreciate our customers’ perspectives and work together for a better future.
Beyond our responsibility to customers, we are responsible to people, animals and the communities and environment in which we live. We are dedicated to assuring people that the products they use have been tested properly for safety and efficacy. We are committed to the highest levels of animal welfare. And we provide services that help develop new medicines, protect the environment and food supplies and make the world a healthier and safer place.
At Envigo, we exist to help our customers secure the potential of their research and develop products that enhance and enrich life.
Not all products are stocked locally; extended lead time and additional fees may apply. Many diets are available in certified format designated by a “C” following the product code. When diets are certified a representative sample is tested for a panel of contaminants. If not stocked as certified, certification can be made available upon request. Minimum order size and additional charges may apply.
As a researcher, you want to have as much control as possible over what goes into your study animals. At Envigo, we understand that. That is why we developed Teklad Global Rodent Diets®.
Teklad Global Rodent Diets® are a special integrated range of vegetarian laboratory rodent diets developed to be nutritionally complete for various life stages from breeding through long-term maintenance. Global rodent laboratory diets contain levels of protein, energy, vitamins and minerals that are more appropriate to the needs of modern biomedical research studies.
Furthermore, in global rodent diets particular attention has been placed on avoiding, as far as practical, ingredients that are reported to have adverse confounding effects on experimental results. This has resulted in a range of Teklad rodent laboratory diets that contain:
No fish meal
No meat meals or meat by-products
No alfalfa meal
No soybean meal or reduced levels
No animal fat
By excluding animal by-products, the presence of nitrosamines (a potential carcinogen) is avoided. Exclusion of alfalfa meal reduces chlorophyll, improving optical imaging clarity. Reduction or removal of soybean meal, together with elimination of alfalfa meal, minimizes levels of naturally-occurring phytoestrogens. Phytoestrogens interact with endogenous estrogens and potentially can affect studies in many research areas. Read more about this in these pieces:
Not all products are stocked locally; extended lead time and additional fees may apply. Many diets are available in certified format designated by a “C” following the product code. When diets are certified a representative sample is tested for a panel of contaminants. If not stocked as certified, certification can be made available upon request. Minimum order size and additional charges may apply.
Traditional rodent diets were formulated decades ago based on understanding of rodent nutrition, ingredients, and diet manufacturing at the time. While traditional diets will supply the known nutrient needs of your laboratory animals, we recommend you consider the use of a diet from our newer global diet line for your modern research needs.
Teklad Global Rodent Diets® are modern formulas designed to reduce research variables. Specifically, these diets contain more appropriate nutrient levels, and limit or exclude ingredients that are reported to have effects on a wide variety of research endpoints.
Lower, more appropriate protein levels can improve survival and reduce morbidity
Vegetarian with no nitrosamines (a potential carcinogen)
Formulated to exclude alfalfa meal, greatly improving fluorescent imaging clarity
Formulated to exclude or lower soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
Extruded rodent diets dramatically reduce clumping and hardness after autoclaving (2018SX , 2019S , 2020SX ), and in general result in less diet waste and cleaner cages
Teklad rodent diets are natural-ingredient diets specifically formulated to provide the proper balance of all known nutrients considered essential for the growth, maintenance, and reproduction of rats, mice, gerbils and hamsters. These diets conform to the nutrient requirements for rodents established by the National Research Council (1995).
Teklad rodent diets provide uniform nutrition. They are fixed-formula diets designed to minimize the nutrient variances which otherwise could occur if the ingredient composition of a diet were altered from one batch to the next.
Protein is supplied primarily by plant sources. Supplemental amino acids are added to provide the proper amount and balance of essential amino acids. All rodent diets are fortified with vitamins and minerals to help support the regulation of body fluids and the proper functioning of body systems to ensure the adequate growth, maintenance, and reproduction of research rodents. Autoclavable diets are supplemented with additional vitamins to compensate for losses that occur during autoclaving. Since our diets are nutritionally complete and balanced, it is not necessary to add dietary supplements.
There is no definitive point where one is able to predict when a specific diet will spoil or become deficient in one or more nutrients. The common guideline of a six month shelf life is based on longstanding practice in North America. In Europe and Asia, differences in local practices and regulatory oversight have led to Teklad standard natural ingredient diets being routinely used out to nine months and sometimes 12 months post-manufacture. This practical experience, along with literature support and vitamin testing over time, gives us confidence that these diets continue to support animal health and study integrity out to at least nine months post-manufacture. Please refer to your institution for guidance if you are unsure of local policies.
Recommended storage conditions:
Cool and dry; at or below 70 degrees fahrenheit with humidity ideally below 50%, but up to 65% is acceptable
Clean and free of pests
In original packaging or in a container that prevents continuous exposure to light and minimal exposure to air
Standard natural ingredient rodent diets are complete diets for rats, mice, gerbils and hamsters, that should be allowed ad libitum access to the diet. Fresh water should be available at all times.
Several references cite use of tamoxifen-containing diets for models with Cre under the control of a mutated estrogen receptor. Envigo Teklad diets makes a variety of tamoxifen-containing diets customized to meet your research needs. We also make a variety of doxycycline-containing diets for tet regulated systems. If you have any questions, don’t hesitate to consult a nutritionist.
Teklad stocks tamoxifen and tamoxifen citrate
Tamoxifen is added to the diet as a tamoxifen-sucrose mixture. Users are encouraged to use the stocked supply. However, Teklad will continue to work with customer prepared mixes. If you choose this option, please consult a nutritionist for additional information about preparing and sending the mixture.
Users are encouraged to select from the stocked options below supply readily available to ship within days.
Teklad offers diet with USP grade tamoxifen and tamoxifen citrate
Tamoxifen mg per kg diet
Daily tamoxifen mg per kg body weight1
Diet code (Teklad supplied tamoxifen)
Diet code (Teklad supplied tamoxifen)
Natural colored
Red
250
40
TD.130855
TD.130856
500
80
TD.130857
TD.130858
400 citrate2
40
TD.130859
TD.130860 3
1 Assumes 20-25 g body weight and three-four g intake 2 Tamoxifen citrate is 66% tamoxifen 3 Referred to as TAM400/CreER in Europe (TD.55125 )
Please add 5-10 day lead time for irradiated diets; minimum 3 kg orders are required for stocked and customized items.
These diets all have tamoxifen premixed with ~five percent sucrose as a palatability enhancer; however, feed aversion may still occur. If intake is a problem, see below for advice.
Teklad Global 2016 — base diet in these examples — is only one of several minimal phytoestrogen diets Teklad produces. Consult a nutritionist about use of other base diets.
Key planning information
Minimum order quantity is three kg, sufficient for feeding ~20 mice for one month
Store diet refrigerated and plan to use within six months
Typical lead time is two weeks (four weeks if irradiated)
Irradiation (optional) minimal dose of 20 kGy (Must be requested at time of order)
To place an order: contact Teklad Customer Service at 800.483.5523 or initiate order online
Mice need time to adjust
Plan for:
Initial reduction in food intake and weight loss
Daily observation of animal tolerance — consult your IACUC for monitoring metrics
Intervene when necessary
Other researchers have the following advice
If intake seems to be a problem:
Determine if a lower dose is effective for your model by conducting a tamoxifen dose feeding trial
Gradually acclimate mice by mixing tamoxifen-containing pellets with regular feed pellets
Wet the food, then place in a dish inside the cage (requires daily replacement)
Feed tamoxifen diet on weekdays, regular diet on weekends
Alternate weeks (two weeks on tamoxifen diet, one week off) for longer treatments
Safe handling of tamoxifen diets
Tamoxifen is a selective estrogen receptor modulator (SERM) meaning it can repress actions of estrogen or have pro-estrogen effects
Usual dose for therapeutic effects in humans is 20 mg/day. Tamoxifen diets for rodents typically contain ~one to two mg/pellet
Accidental tamoxifen exposure can be minimized by using typical lab precautions of lab coat, gloves, and mask when handling the diet.
Your chemical safety department should be contacted for additional institution specific guidelines for handling and disposal of tamoxifen containing diets.
Key points from literature
Length of treatment varies from one to two weeks1,2,5,6,7,8 to one to two months3,4,8
Pure tamoxifen1,5,8 and tamoxifen citrate1,2,3,4,6,7 are both effective Usual tamoxifen doses are ~40-80 mg per kg body weight per day
Typical inclusion for pure tamoxifen is 250 mg8 or 500 mg1,5 and for tamoxifen citrate is 400 mg per kg diet1,2,3,4,6,7
Initial weight loss of ten % is reported1,2,4,7,8, associated with reduced food intake2
Subsequent recovery of body weight after returning to regular diet may be compromised by gene inactivation2,7
Selected tamoxifen references
1 Andersson KB, Winer LH, Mork HK, Molkentin JD, Jaisser F. 2010. Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts. Transgenic Res 19:715-725.
2 Chiang PM, Ling J, Jeong YH, Price DL, Aja SM, Wong PC. 2010. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci USA 107:16320-16324.
3 Kardakaris R, Gareus R, Xanthoulea S, Pasparakis M. 2011. Endothelial and macrophage-specific deficiency of P38alpha MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice. PLoS One 6:e21055.
4 Kiermayer C, Conrad M, Schneider M, Schmidt J, Brielmeier M. 2007. Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate. Genesis 45:11-16.
5 Koitabashi N, Bedja D, Zaiman AL, Pinto YM, Zhang M, Gabrielson KL, Takimoto E, Kass DA. 2009. Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models. Circ Res 105:12-15.
6 Kratsios P, Catela C, Salimova E, Huth M, Berno V, Rosenthal N, Mourkioti F. 2009. Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. PCirc Res 106:559-572.
7 Miro-Murillo M, Elorza A, Soro-Arnaiz I, Albacete-Albacete L, Ordonez A, Balsa E, Vara-Vega A, Vazquez S, Fuertes E, Fernandez-Criado C, Landazuri MO, Aragones J. 2011. Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression. PLoS One 6:e22589.
8 Welle S, Burgess K, Thornton CA, Tawil R. 2009. Relation between extent of myostatin depletion and muscle growth in mature mice. Am J Physiol Endocrinol Metab.Oct;297(4):E935-40.
If you have any questions regarding tamoxifen diets, please don’t hesitate to contact a nutritionist at askanutritionist@envigo.com.
A few mineral adjusted formulas are shown below. Please contact us for additional formulas of this nature or for more information about altering the mineral profile of a diet. Read below for more information.
Unique protein ingredients may be necessary to minimize background levels of certain minerals. Other steps taken to minimize background mineral contamination include the use of reagent grade minerals when necessary or omission of certain ingredients. Specialized mineral premixes may be used in these diets, or minerals are added individually to the diet in order to control the level of specific minerals.
With the exception of sodium, it is necessary to use refined ingredients to achieve the lowest possible levels of minerals in a diet.
From this mineral deficient base, various levels of minerals can be added back. Some formulas adjust multiple minerals, and other related nutrients.
Contact usto discuss other possibilities for the minerals listed above, and for those minerals not listed here.
