Harlan Teklad动物饲料Isoflavone adjusted

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Isoflavone adjusted

Isoflavone adjusted

Isoflavones, a type of phytoestrogen, are found in soy protein. Most traditional standard diets have soybean meal as a major ingredient, and therefore are a significant source of isoflavones. Please refer to FAQ section for more information about phytoestrogens.

In contrast, casein-based purified diets such as AIN-76A, AIN-93G, AIN-93M, and formulas with similar ingredients, are essentially free of isoflavones. This type of diet is sometimes used for research that requires a minimal isoflavone background. This type of diet can be used as the background to which isoflavones such as genistein (supplied by the customer) can be added.

An alternative to a purified, casein-based diet is a natural ingredient diet from our global rodent diet line. Several diets in this line contain minimal isoflavone/phytoestrogen levels and are commonly used for research that requires a minimal isoflavone/phytoestrogen background. This type of diet can also be used as the background to which isoflavones such as genistein (supplied by the customer) can be added.

Harlan Teklad动物饲料Rabbit, swine and other species diets

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Rabbit, swine and other species

Rabbit, swine and other species diets

The most common custom rabbit diets are those with a standard diet base and added cholesterol. Typically, the added cholesterol ranges from 0.25% to two percent. Additional fat can also be a feature of these formulas. To preserve pellet quality we recommend no more than six percent additional fat. Added fat is most often supplied as peanut oil, corn oil, coconut oil, or a combination. We recommend the Teklad base diets 2030 or 2031.

Rabbits do not readily consume purified diet. When specific nutrient manipulations are necessary, hybrid diets or at least some alfalfa meal inclusion is recommended. Contact us for formula examples or to discuss your specific needs.

Most often, customized diets for swine feature natural ingredients with added fat and cholesterol. Here are three variations on this theme:

  • TD.92033 Swine diet (15% lard, 1.2% cholesterol)
  • TD.92052 Swine diet (15% lard, 1.5% cholesterol)
  • TD.93296 Swine diet (15% lard, two perecent cholesterol)

We recommend these diets in meal/powder form, as pellets are not very durable. Other natural ingredient and purified diets with various nutrient manipulations are available. Contact us for further information.

The most common custom Guinea pig diets are those with a standard diet base (such as Teklad 2040 or 2041) and added cholesterol.

Guinea pigs do not readily consume purified diets, so when specific nutrient manipulations are necessary, hybrid diets (mixture of refined and natural ingredients) are recommended. At the very least it is advisable to retain some alfalfa meal in the diet. Contact us for further information.

Most times, diets that are developed for mice and rats are suitable for hamsters and gerbils, and vice versa. We may advise increasing specific nutrients in a purified diet for hamsters and gerbils. Contact us for further information.

Depending on the focus of your research, customized diet for non-human primates can contain natural ingredients, refined ingredients, or a mixture of both. Custom diets for primates often feature adjustments in fat type, fat level, and cholesterol. Contact us for further information.

Harlan Teklad动物饲料Accreditations and certifications

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Accreditations and certifications

Accreditations and certifications

At Envigo, we are dedicated to providing a broad range of research models and related services to the pharmaceutical and biotechnology industries, government, academia, and other life science organizations. We are committed to helping researchers realize the full potential of their critical research projects as we fulfill our mission to work together to build a healthier and safer world.

In order to build trust and confidence with our customers, we strive to consistently deliver scientific excellence. Included below is a list of our most recent certificates and accreditations.

Accreditations and certifications

Certifications

 

Accreditations and certifications

Accreditations

 

Harlan Teklad动物饲料Vision, mission and values

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Vision, mission and values

Vision, mission and values

Vision

Working together to build a healthier and safer world

Mission

To be the best company to work with and the best company to work for

Values

Doing our best work, together, every day
Caring about each other, our animals and the environment
Being honest and respectful
Always learning, challenging and improving

Harlan Teklad动物饲料Customer supplied ingredients

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Customer supplied ingredients

Customizing diets for all types of research needs

Customer supplied ingredients

When your experiments require the addition or application of certain compounds to your animal research subject, you can consider adding your medications or compounds to your animal’s diet. Envigo has experience customizing diets for all types of research needs, and that includes introducing additives as a convenient way to medicate lab animals. Simply turn to one of our expert staff nutritionists to determine whether it is a viable option.

Medications or compounds supplied by your investigator are referred to as “customer supplied ingredients” or “customer reserves,” and they can be added to most diets. Generally, if the stability or activity of the compound is not compromised during manufacture or further processing such as irradiation, adding an ingredient can be a smart option for simplifying your feeding and medicating schedules. Also, the inclusion rate of any given compound is adjusted to suit your needs, and can be determined in consultation with our expert nutritional staff.

Please use the customer supplied ingredients submission form if you require the addition or application of certain compounds to your animal research subject.

Some common customer supplied compounds include:

  • Cuprizone (also now stocked)
  • Tamoxifen (also now stocked: US, EU)
  • Purified fatty acids (DHA, EPA)
  • Curcumin
  • Rosiglitazone
  • Statins
  • Antibiotics
  • Valproate
  • Piroxicam
  • Berry powders
  • Bisphenol A (BPA, in diluted form)

When adding a compound to a diet, we will work with you to be sure that it is appropriate for our diet formulation procedures and can be done safely.

  • We require a safety data sheet or other relevant safety and usage information
  • We have an obligation to maintain a safe work environment. This typically applies to drugs, experimental compounds and chemicals
  • Food products generally will not require safety information, although information about nutrient content, reason for use, etc. is helpful in the design of diets

  • Water is added as a pelleting aid. Pellets are formed under pressure but no external heat is applied
  • Sometimes the drying process can be modified if heat stability is questioned
  • It is your responsibility to determine the suitability of the compound for inclusion into a pelleted diet

  • If you require irradiation, we can customize most diets to be suitable for this sterilization process
  • Once your diet has been produced, we can send it for irradiation. The dose ranges from 20-50 kGy. Diets that are to be irradiated require an additional two weeks for shipment (four weeks total)
  • For diets that are to be irradiated, vacuum packaging may be beneficial. Both irradiation and vacuum packaging must be requested when ordering
  • We defer to you to determine the suitability of the compound for irradiation

  • Inform us on a g/kg diet or percentage basis, how much of the compound you want in the diet
  • If you need to calculate a dose based on animal body weight, we can help convert that to g/kg diet
  • Depending on the choice of base diet and the nature of the added ingredient(s), more than a ten percent dilution is generally not advisable
  • To limit differences between the control and experimental diets you may want to consider using a control diet that uses similar ingredients and has gone through the same production process

  • Send extra compound (approximately enough for one more kg than you have ordered) so that we can yield the desired amount of diet
  • If we have not received enough compound, we will use the entire amount and make as much diet as possible, unless special arrangements can be made

  • If you plan to use the compound more than once and stability with storage is not an issue, we can maintain an inventory for you and store it appropriately, per your instructions
  • Unless otherwise instructed, we will return any remaining compound with your shipment, but we do not dispose of the compound
  • If you would like your compound retained for future use, please supply us with a retention document

Harlan Teklad动物饲料Brexit FAQs

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Brexit FAQs

Brexit FAQs

Envigo is continuously monitoring, preparing and updating its guidance to customers as we approach the key dates of the Article 50 separation of the United Kingdom from the European Union (aka “Brexit”). Envigo established a Brexit task force consisting of senior leadership from key areas of our business to ensure ongoing business continuity for both Envigo and its customers.

This task force continues to meet regularly in order to prepare and implement business process plans and resourcing to anticipate and minimize the impact of Brexit on our business. The following FAQs have been prepared as current guidance and is continually updated as the position between the British Government and the EU develops.

Brexit is a priority for Envigo and if you have any concern, please contact us at brexit@envigo.com.

Download the Brexit FAQs .

    Trade (Import / Export / Supply Chain)

  • Will there be tariffs applied to animal costs under WTO?

    Laboratory animals currently have no tax added for movement in to the EU and across the EU, this position will remain the same under WTO

    Prices for 2021 are being reviewed as normal and will be confirmed in due course.

  • Will there be changes in documentation needed for movements of animals in or out of the UK?

    Import to UK Changes:
    Envigo’s current understanding is that there will be limited change in terms of documentation required. 

    DEFRA have now confirmed that no additional vet checks on arrival will be required

    Also customers can use the AHPA License for the import into the UK of live rodents or lagomorphs for research. Our Customer Services team are talking to the relevant customers and can advise any new customers as required

    Our Customer Services team is working directly with customers to make the necessary changes to Incoterms

    Export from UK Changes:
    Envigo understands that the export documentation will need to be agreed with the EU and may require an additional licence per shipment. This may take an additional time to secure plus an additional vet check may be required prior to shipment. We are working with EU groups to clarify this position and will update customers once a firm position is confirmed.

    Documentation:
    Exact documentation requirements are to be clarified, please contact your customer services representative if you have immediate concerns.

  • Will there be any other impact on the movement of animals in and out of the UK?

    The main impact we currently predict is additional delays in shipments due to:

    Export license requests may add time to the process from PO to shipment for small animals being shipped from the UK to the EU. Vet checks might be required at Border Inspection Posts at the airport of arrival.

    Additional CITES might be required and thus may add additional time for shipments of animals requiring to travel under CITES from the EU to the UK.

  • Will there be tariffs on any other goods imported in and out of the UK under WTO?

    Under WTO terms the Envigo team have assessed that there will be additional tariffs on certain goods including our Teklad diet shipments into the UK. Additional costs are being assessed and any cost impact to clients will be conveyed to customers via our commercial sales team as soon as possible.

  • Has Envigo ensured that its supply chain for its Operations are ready for the change on 1st Jan?

    Envigo’s Procurement team continues to work with it’s key suppliers in the UK to ensure that supply chains are secure for the post Brexit period. The team are encouraging suppliers to ensure that they have sufficient stock to cover any transition period at the beginning of January.

  • What will the impact be on the movement of biological products (UK to customer EU and EU to UK)?

    We are working with the governmental authorities in the relevant countries together with our international couriers to determine labelling / commercial invoice / payment of VAT / export license & vet check requirements. We will update all parties once further clarity is obtained. We are sure that this will be determined to ensure continuity of these services as we transition to the post Brexit position.

  • Does Envigo think movement of animals in and out of the UK will have the changes in place ready for 1st Jan?

    Envigo recommends that its clients do not request animals deliveries in or out of the UK during the first two weeks of January in order to ensure that all changes at borders and documentation are in place. If there is a requirement for a shipment early in January we would request that you contact your customer services representative as early as possible in December order that the necessary plans can be put in place.

  • Are there any specific concerns in relation to shipments to Ireland?

    The changes in movement of goods from UK to both Northern and Southern Ireland is still unknown – further clarification will be provided when we have more information.

    Talent

  • What proportion of Envigo’s UK employees are EU nationals?

    Less than 6% of Envigo’s UK employees are EU nationals. We have worked with all of these employees to ensure they have the relevant rights to live / work in the UK or EU as appropriate

  • What is Envigo’s expectation of the impact of immigration challenges to staffing your UK-based operation?

    This is not expected to have significant impact as Envigo has separate distribution centres in both the UK and EU to enable us to continue to operate under the most favourable trading environment for our customers regardless of trading arrangements between the UK and the EU, or between the UK, EU and the rest of the world. We are committed to recruiting and retaining the best people and to pursue our mission to be the best company to work with and the best company to work for.

    Financial

  • What will be the impact on Envigo’s finances?

    Envigo is financially stable and resilient: Though there might be minor changes arising from the Brexit transition, we believe that there will not be any significant adverse impact to the business and we will continue to invest in world-class operations and innovation post Brexit.

  • Impact of exchange rate movements on costs, profitability and competitive position

    Exchange rate movements are an inevitable fact of the business environment and occur because of numerous factors including, inflation, government fiscal policy, real gross domestic product GDP and expectations around future economic performance and the impact of speculative currency investment. In this regard, they are not deemed to be solely a Brexit specific issue. Exchange rate risk is mitigated by Envigo due it being an international business, which has regional operational centres in proximity to the customer base incurring costs in the same currency of sale.

    Data Protection/GDPR

  • What is will be the status of the General Data Protection Regulation (2016/679) (GDPR) after the transition period.

    The UK is committed to maintaining the high standards of the GDPR and the government plans to incorporate it via the European Union (Withdrawal) Act 2018 into UK law alongside the Data Protection Act 2018, at the end of the transition period.

  • What safeguards will be in place for 1. UK to EEA Personal Data flows; 2. EEA to UK Personal Data flows; and, 3. UK sharing data outside the EEA after the transition period?
    1. The UK government has stated that transfers of Personal Data to the EEA will not be restricted and that no additional steps are necessary at this time.
    2. The European Commission is presently deliberating on an adequacy decision under Article 45(3) of the GDPR which would enable the transfer of personal data from EEA states to the UK without requiring any further safeguards. Pending such an adequacy decision or in the absence thereof, Envigo is putting in place approved safeguards in the form of standard contractual clauses.
    3. Rules for sharing data with countries outside the EEA will remain similar.The UK government has confirmed that there will be transitional provisions to recognise existing EU adequacy decisions and EU-approved transfers safeguards.

    Other

  • What Brexit scenario is Envigo planning for?

    At this stage Envigo is planning for a “no-deal” scenario and have put the necessary actions in place to manage its business on this basis

  • Has Envigo undertaken an internal assessment of what impact Brexit will have on customer’s business operations?

    Yes, Envigo continues to assess the potential impact of Brexit on both our customers and suppliers. In response to Brexit we have:

    • Our internal task force is continuously assessing the overall business risks
    • Developing a range of contingency plans to mitigate the effects
    • Envigo are taking a leading role and working with various industry associations. ABPI, BIA, EARA, and UK government departments (e.g. DEFRA, Home office, Her Majesty’s Revenue and Customs (HMRC)). At this stage there are still uncertainties on specific issues e.g. CITES and as such there are still risks that we continue to try and mitigate against. As a result, we would recommend that cross border shipment in the first two weeks of January be avoided.
  • Have you developed a plan to mitigate the Brexit risks you have identified?

    Yes, and are already initiating action and contingency plans to address potential impacts on our business based upon our current understanding.

  • Does Envigo review and adjust plans based on Brexit negotiations and wider external events?

    Yes, our internal task force is continuously assessing the overall business risks, to ensure the plans are both relevant and appropriate to the current political situation.

  • Whom may we contact to follow up on the responses to Brexit mitigation plans?

    An e-mail address has been established: brexit@envigo.com. This is available for use to allow any specific follow up questions to be raised that you might have in relation to Envigo’s Brexit mitigation plans.

Glossary

ABPI Association of British Pharmaceutical Industry
BIA  Bioindustry Association
CLP  Classification, Labelling and Packaging
CITES  Convention on International Trade in Endangered Species of Wild Fauna and Flora (also known as the Washington Convention)
DEFRA  Department for Environment, Food and Rural Affairs
DPB  Data Protection Bill
EARA  European Animal Research Association
EU27  European Union (the 27 European Union countries involved in Brexit negotiations)
EUWB  European Withdrawal Bill
GDPR  General Data Protection Regulation
HMRC  Her Majesty’s Revenue and Customs
PII  Personally Identifiable Information
WTO  World Trade Organization

Harlan Teklad动物饲料Fat/lipid adjusted

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Fat/lipid adjusted

Fat/lipid adjusted

There are numerous possibilities in adjusting both the level and source of fat in a diet. If your primary interest is inducing atherosclerosis or obesity, additional information can be found on our Teklad atherogenic and diet induced obesity (DIO) diet pages. Depending on your research goals and level of desired fat supplementation, fats can be added to a standard natural ingredient diet or a purified diet.

Purified ingredients are refined to the point of chemical simplicity and allow for extreme fat levels such as no fat diet TD.03314 or very high fat ketogenic diet TD.96355 . Unless adjustments are made to the level of fiber, diets with high fat levels will have a greater caloric density since fat contains 9 kcal/g versus 4 kcal/g for carbohydrate or protein. Animals are good at regulating caloric intake, therefore it is common to adjust other nutrients (vitamins, minerals, protein) relative to energy content to account for differences in feed intake.

Specific fats can be utilized as in this essential fatty acid deficient diet TD.84224 or to provide high levels of omega-3 polyunsaturated fat from flaxseed or fish oil. Normally, 1-2% fat from plant sources like corn or soybean oil will supply sufficient levels of essential fatty acids. Additional fat provides energy and can influence palatability due to effects on taste and texture of the diet.

Mixtures of fats can be used to mimic a Western or Mediterranean diet fatty acid profile. Contact us for a table comparing the fatty acid composition of several stocked fat sources (solid fats, oils).

We also commonly work with customer supplied oils and purified fatty acids such as DHA and EPA. If you prefer to mix fat sources in your lab, ask about a basal mix. Basal mixes are supplied in powder form and often allow you to use one diet mix for creating several different diets.

If fat stability is a concern, contact a nutritionist to discuss options for diet drying, vacuum packaging, and synthetic antioxidant supplementation.

Example diets mentioned above

 

Contact us to discuss the use of these example diets or one that better meets your needs.

Harlan Teklad动物饲料Our brand story

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Our brand story

Our brand story

Envigo’s customers conduct research and develop products that have the potential to improve lives. But achieving this potential is becoming increasingly difficult.

We believe that for our customers to achieve their goals, they need to trust and be absolutely confident in the company they choose to help them with their research, products and services.

We understand the only way we can create this trust and confidence is by consistently delivering scientific excellence and outstanding customer service.

At Envigo, we are proud of our customer-centric culture which makes us responsive to every customer, no matter their size, continually optimizing their product delivery and research programs to help ensure consistently clear results.

Our ability to combine scientific excellence with empathetic working relationships is what differentiates us. We always seek to understand our customers’ goals and challenges, appreciate our customers’ perspectives and work together for a better future.

Beyond our responsibility to customers, we are responsible to people, animals and the communities and environment in which we live. We are dedicated to assuring people that the products they use have been tested properly for safety and efficacy. We are committed to the highest levels of animal welfare. And we provide services that help develop new medicines, protect the environment and food supplies and make the world a healthier and safer place.

At Envigo, we exist to help our customers secure the potential of their research and develop products that enhance and enrich life.

Our brand story

 

 

Harlan Teklad动物饲料Mineral adjusted diets

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Mineral adjusted diets

Mineral adjusted diets

A few mineral adjusted formulas are shown below. Please contact us for additional formulas of this nature or for more information about altering the mineral profile of a diet. Read below for more information.

Formula examples:

  • TD.80396       Iron deficient diet
  • TD.85419       Zinc deficient diet
  • TD.88239       Potassium deficient diet
  • TD.95027       Low calcium diet (0.4% P)
  • TD.96348       Diet (20% lactose, 2% Ca, 1.25% P)
  • TD.92163       Selenium deficient diet
  • TD.95125       Iodine deficient (0.15% PTU)

Unique protein ingredients may be necessary to minimize background levels of certain minerals. Other steps taken to minimize background mineral contamination include the use of reagent grade minerals when necessary or omission of certain ingredients. Specialized mineral premixes may be used in these diets, or minerals are added individually to the diet in order to control the level of specific minerals.

With the exception of sodium, it is necessary to use refined ingredients to achieve the lowest possible levels of minerals in a diet.

From this mineral deficient base, various levels of minerals can be added back. Some formulas adjust multiple minerals, and other related nutrients.

Contact us to discuss other possibilities for the minerals listed above, and for those minerals not listed here.