产品基本信息

产品名称：RGD-荧光近红外750

储存条件：-15℃避光防潮

保质期：24个月

产品物理化学光谱特性

分子量：~1600

溶剂：DMSO

激发波长(nm)：757

发射波长(nm)：779

产品介绍

近红外荧光光学成像（又称活体成像）是一种在分子水平上研究小动物疾病的技术。水和生物组织在近红外（650-900纳米）中具有小的吸光度和自荧光，从而允许有效的光子进出组织，且组织内散射较低。通过这个近红外光线，生理上丰富的分子如血红蛋白、氧血红蛋白和脱氧血红蛋白对光的吸收也降到低。具有生物相容性荧光剂的活体成像系统正在开发和优化，以用于近红外光谱区域-确保大的光穿透和高的灵敏度。细胞粘附分子整合素参与多种肿瘤的血管生成和转移。整合素在活化的内皮细胞和快速生长的实体瘤细胞中明显上调，而在静止的血管和大多数正常组织中表达低。 iFluor 750标记的单体精氨酸-甘氨酸-天冬氨酸（RGD）肽c（RGDyK）专门针对细胞培养和活体内的整联蛋白。 iFluor 750-c（RGDyK）的体内功效取决于许多因素，包括受体亲和力，特异性，分子大小，总分子电荷，亲水性和代谢稳定性。

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参考文献

99mTc-Glu-c(RGDyK)-Bombesin SPECT Can Reduce Unnecessary Biopsy of Masses That Are BI-RADS Category 4 on Ultrasonography
Authors: Ji T, Gao S, Liu Z, Xing H, Zhao G, Ma Q.
Journal: J Nucl Med (2016): 1196

In Vivo Biodistribution and Anti-Tumor Efficacy Evaluation of Doxorubicin and Paclitaxel-Loaded Pluronic Micelles Decorated with c(RGDyK) Peptide
Authors: Chen Y, Zhang W, Huang Y, Gao F, Fang X.
Journal: PLoS One (2016): e0149952

Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization
Authors: P and ya DN, Hantgan R, Budzevich MM, Kock ND, Morse DL, Batista I, Mintz A, Li KC, Wadas TJ.
Journal: Theranostics (2016): 698

c(RGDyK)-decorated Pluronic micelles for enhanced doxorubicin and paclitaxel delivery to brain glioma
Authors: Huang Y, Liu W, Gao F, Fang X, Chen Y.
Journal: Int J Nanomedicine (2016): 1629

Dual-functional c(RGDyK)-decorated Pluronic micelles designed for antiangiogenesis and the treatment of drug-resistant tumor
Authors: Chen Y, Zhang W, Huang Y, Gao F, Fang X.
Journal: Int J Nanomedicine (2015): 4863

Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles
Authors: Gao Y, Zhou Y, Zhao L, Zhang C, Li Y, Li J, Li X, Liu Y.
Journal: Acta Biomater (2015): 127

Comparison of two new angiogenesis PET tracers 68Ga-NODAGA-E[c(RGDyK)]2 and (64)Cu-NODAGA-E[c(RGDyK)]2; in vivo imaging studies in human xenograft tumors
Authors: Oxboel J, Br and t-Larsen M, Schjoeth-Eskesen C, Myschetzky R, El-Ali HH, Madsen J, Kjaer A.
Journal: Nucl Med Biol (2014): 259

The C(RgdyK)-conjugated Fe3O4 nanoparticles with high drug load for dual-targeting integrin alpha(v)beta3-expressing cancer cells
Authors: Guo L, Ding W, Zheng LM.
Journal: J Nanosci Nanotechnol (2014): 4858

Design and biological evaluation of (9)(9)mTc-N(2)S(2)-Tat(49-57)-c(RGDyK): a hybrid radiopharmaceutical for tumors expressing alpha(v)beta(3) integrins
Authors: Ocampo-Garcia BE, Santos-Cuevas CL, De Leon-Rodriguez LM, Garcia-Becerra R, Ordaz-Rosado D, Luna-Guitierrez MA, Jimenez-Mancilla NP, Romero-Pina ME, Ferro-Flores G.
Journal: Nucl Med Biol (2013): 481

Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK)
Authors: Kim JH, Kim YH, Kim YJ, Yang BY, Jeong JM, Youn H, Lee DS, Lee JS.
Journal: Angiogenesis (2013): 837